In the current research, the question is raised, what are the most important challenges of not realizing the Resistance Economy model desired by the Supreme Leader of the Islamic Revolution from the perspective of the Discourse of the Islamic Revolution? The answer that can be given is that usury and the usurious Economy, due to dominating the unproductive economic model and promoting profit-seeking, cause the destruction of the foundations of the Resistance Economy (including endogeneity, production-oriented and popular principle) which They are in contradiction with the Discourse of the Islamic revolution. The findings of the research show that the way to achieve a model of Resistance Economy is to apply the negation and sanctity of usury in the banking field, to reform the financial system governing the country's Economy based on the negation of usury, and to deal with any type of usury both in the public sector and in the private sector. We are private, which is also specified in the statements of the supreme leader of the revolution. To achieve these goals, we need jihadi efforts and rely on internal abilities, entrepreneurship and productive employment. The method of the current research is descriptive-analytical in which the opinions and statements of the Supreme Leader of the Islamic Revolution in connection with the negation and sanctity of usury are cited.